Role of cell quiescence in glioblastoma cytotoxic resistance and strategies for therapeutic intervention

Abstract

The understanding of how cancer stem cells behave is important in understanding how tumors are initiated and how they recur following initial treatment. More specifically to understand how cancer stem cells behave, the different signaling mechanisms orchestrating their growth, cell cycle dynamics, differentiation, trans-differentiation, and survival following cytotoxic challenges need to be deciphered. Ultimately, this will advance the ability to predict how these cells will behave in individual patients and under different therapeutic conditions. Glioblastoma (GBM) stem cells, which have low proliferative capacity, exhibiting characteristics similar to quiescent stem cells are a likely sour..